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STAGE-SPECIFIC TREATMENT AND CLINICAL OUTCOMES OF PATIENTS WITH HEPATOCELLULAR CANCER AT THE UNIVERSITY COLLEGE

H A Alimi1, M Osundina1, M Ijikoyejo1

  • 1Department of Medicine, Gastroenterology Unit, University College Hospital, Ibadan.

Annals of Ibadan Postgraduate Medicine
|August 25, 2025
PubMed

Insights

Hepatitis B Virus is the primary risk factor for Hepatocellular Carcinoma (HCC). Hepatic resection significantly improves survival rates for HCC patients, offering the best clinical outcome.

Area of Science:

  • Hepatology
  • Oncology
  • Gastroenterology

Background:

  • Hepatocellular carcinoma (HCC) presents a significant global health challenge with high mortality rates.
  • Understanding risk factors, treatment patterns, and outcomes is crucial for improving patient care.
  • This study focuses on HCC within a specific hospital setting over a five-year period.

Purpose of the Study:

  • To identify the primary risk factors associated with Hepatocellular Carcinoma (HCC) in the study population.
  • To analyze the treatment modalities employed for different stages of HCC.
  • To evaluate the clinical outcomes, particularly overall survival, based on treatment received.

Main Methods:

  • A retrospective study design was utilized, analyzing data from patients diagnosed with HCC between January 2019 and December 2023.
  • Data collection included demographics, clinical information, and diagnostic investigations.
  • Statistical analysis was performed using SPSS version 20 to determine overall survival and other parameters.

Main Results:

  • Hepatitis B Virus infection was identified as the predominant risk factor for HCC in 73.9% of patients.
  • Alcohol consumption was noted in 35% of male patients.
  • Hepatic resection demonstrated the longest median survival time (18 months) compared to chemotherapy (3 months) and palliative care (1.2 months).

Conclusions:

  • Hepatitis B Virus is the leading risk factor for HCC in this region.
  • Hepatic resection is associated with the most favorable survival outcomes for HCC patients.
Abstract

Keywords:
ChemotherapyHBVHepatocellular carcinomaLiver cirrhosis.ResectionRisk factors

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