Organoarsonate- and Dimethylarsinate-Functionalized Hexamolybdates(V): A Multifaceted Study on Synthesis, Structural...

Area of Science:

• Inorganic Chemistry
• Materials Science
• Medicinal Chemistry

Background:

• Arsenomolybdates are a class of inorganic compounds with potential applications in catalysis and medicine.
• Functionalization of these clusters allows for tuning of their properties and exploration of new applications.

Purpose of the Study:

• To synthesize and characterize novel dimethylarsinate-functionalized arsenomolybdates(V).
• To investigate the structural, solution-phase, and gas-phase properties of these compounds.
• To evaluate the antibacterial activity of the synthesized polyanions.

Main Methods:

• One-pot aqueous synthesis method.
• Single-crystal X-ray diffraction, thermogravimetric analysis, elemental analysis for solid-state characterization.
• Multinuclear NMR spectroscopy for solution-phase stability.
• Electrospray ionization mass spectrometry and tandem mass spectrometry for gas-phase behavior.
• Antibacterial screening against Escherichia coli, Bacillus subtilis, Listeria monocytogenes, Salmonella enterica, and Vibrio parahaemolyticus.

Main Results:

• Synthesis and structural characterization of 11 novel dimethylarsinate-functionalized arsenomolybdates(V) with a reduced hexanuclear {MoV6O24} core.
• Diverse organoarsonate, arsenate, or arsenite groups were successfully incorporated, including carboxylated, fluorinated, brominated, and azido derivatives.
• Three of the synthesized polyanions demonstrated moderate antibacterial activity against selected bacterial strains.
• First-time synthesis of 3,5-bis(carboxy)phenylarsonic acid reported.

Conclusions:

• Novel functionalized arsenomolybdates can be efficiently synthesized using a straightforward aqueous method.
• The structural diversity and tunable functionalization of these polyanions are confirmed.
• The moderate antibacterial activity suggests potential for further development in antimicrobial applications.