Tumor-infiltrating CD103+CD8+hnRNPA2B1+ tissue-resident T cells indicate poor prognosis in patients with clear cell renal cell carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Tumor-infiltrating CD103+CD8+hnRNPA2B1+ T cells are linked to worse outcomes in clear cell renal cell carcinoma (ccRCC). Higher infiltration predicts unfavorable prognosis and may indicate response to PD-1 immunotherapy.
Area Of Science
- Immunology
- Oncology
- Translational Medicine
Background
- Tumor heterogeneity and complex immune microenvironments hinder immunotherapy candidate identification using dominant biomarkers.
- CD8+ T cells, especially tissue-resident subsets like CD103+CD8+, are linked to better outcomes in many cancers, but their role in renal cancer is understudied.
Purpose Of The Study
- To investigate the prognostic significance of tumor-infiltrating CD103+CD8+ T cells and their subsets, specifically CD103+CD8+hnRNPA2B1+, in clear cell renal cell carcinoma (ccRCC).
- To evaluate the association of these T cell subsets with patient prognosis and response to PD-1 immunotherapy.
Main Methods
- Multiplex immunofluorescence staining was used to assess CD103+CD8+ T cell subsets in ccRCC tissues.
- Correlation analysis was performed between T cell infiltration levels and patient clinicopathological features and prognosis.
- Single-cell transcriptomics data from ccRCC patients treated with PD-1 therapy were analyzed to compare hnRNPA2B1 expression in responders versus nonresponders.
Main Results
- Infiltration of CD103+CD8+ T cells, CD103+CD8+hnRNPA2B1+ T cells, and CD103+CD8+Bhlhe40+ T cells was significantly higher in ccRCC tissues compared to normal adjacent tissues (P < 0.01).
- Higher infiltration of these subsets correlated with worse overall survival and served as independent prognostic factors for ccRCC patients (P = 0.0144 and P = 0.013, respectively).
- Tumor-infiltrating CD8+ T cells from PD-1 therapy responders showed higher hnRNPA2B1 expression than nonresponders.
Conclusions
- Tumor-infiltrating CD103+CD8+hnRNPA2B1+ tissue-resident T cells represent an unfavorable prognostic factor in ccRCC.
- These T cell subsets may serve as predictive biomarkers for patient response to PD-1-based immunotherapy.
- Further research into these specific T cell populations could refine immunotherapy strategies for ccRCC.
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