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Updated: Sep 10, 2025
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
NiH-Catalyzed Regioselective Hydroamidation of Unactivated Alkenes with Dioxazolones
Dong-Jie Li1, Hai-Yang Hu1, Bai-Qun Ruan1
1College of Chemistry and Materials Science, Sichuan Normal University, 5 Jingan Road, Chengdu 610068, People's Republic of China.
Abstract:
A nickel-catalyzed intermolecular hydroamidation of alkenes with dioxazolones has been developed, enabling the efficient synthesis of valuable β- and γ-amino acid derivatives. The presence of a directing group is pivotal to the reaction's success. This methodology is characterized by mild reaction conditions, high regioselectivity, with excellent functional group tolerance, and the elimination of additional ligand requirements. The practical applicability of this approach was further validated through large-scale reactions and the late-stage functionalization of pharmaceutical molecules.
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