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Updated: Sep 10, 2025

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Covalent Conjugation Strategies for Antifungal Agents: Synthetic Approaches and Therapeutic Potential
Andrzej S Skwarecki1, Marta Skwarecka2
1Department of Pharmaceutical Technology and Biochemistry and BioTechMed Center, Faculty of Chemistry, Gdansk University of Technology, 11/12 Gabriela Narutowicza street, 80-233, Gdańsk, Poland.
Abstract:
The increasing prevalence of invasive fungal infections, alongside rising resistance to conventional antifungal therapies, necessitates the development of improved treatment strategies. This review provides a comprehensive overview of recent advances in the design, synthesis, and biological evaluation of antifungal drug conjugates. Particular emphasis is placed on structural modifications of clinically used antifungal agents-such as azoles, echinocandins, and polyene macrolides-as well as novel conjugates incorporating coumarins, steroids, amino acids, and peptides. Conjugation strategies, including covalent attachment to small molecules, polymers, or bioactive moieties, have been employed to improve pharmacokinetic properties, reduce toxicity, and overcome drug resistance. The synthesis methods and biological profiles of selected conjugates are critically discussed, highlighting their potential as candidates for next-generation antifungal therapeutics. This review underscores the versatility of conjugation chemistry as a promising platform for antifungal drug development.
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