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Updated: May 3, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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Effects of Cold and Vibration on Venipuncture Pain Management in Children Aged 2-7 Years Old: Randomized Controlled

Zi-Yun Zhou1,2, Long-Yi Hu2,3, Ming-Li Wang2

  • 1Hunan Provincial Comprehensive Childcare Service Center, Changsha, China.

JMIR Pediatrics and Parenting
|August 25, 2025
PubMed

Insights

Cold and vibration, using the Buzzy device, effectively reduce venipuncture pain and resistance in children. Combining cold and vibration offers the greatest pain relief and improved compliance.

Area of Science:

  • Pediatric pain management
  • Procedural pain reduction
  • Childhood stress mitigation

Background:

  • Venipuncture pain is a significant stressor for children, potentially leading to adverse effects.
  • The Buzzy device offers a promising method for alleviating venipuncture pain in pediatric patients.

Purpose of the Study:

  • To evaluate the individual and combined effects of cold and vibration on venipuncture pain.
  • To assess the impact of these interventions on resistance behaviors in children aged 2-7 years.

Main Methods:

  • 130 children were randomized into control, cold, vibration, or combined cold and vibration groups.
  • The Buzzy device was used for cold, vibration, and combined interventions.
  • Pain and resistance were assessed using validated scales (Face, Legs, Activity, Cry, Consolability Pain Behavior Scale and Children's Behavior Scale).

Main Results:

  • All intervention groups (cold, vibration, combined) showed significantly reduced pain and resistance compared to the control group (P<.05).
  • The combined cold and vibration group demonstrated superior outcomes compared to the vibration-only group (P<.05).

Conclusions:

  • External cold and vibration are effective in reducing procedural pain and enhancing compliance in children during venipuncture.
  • The combination of cold and vibration exhibits a synergistic effect, yielding better results than vibration alone.
Abstract

Keywords:
BuzzyBuzzy deviceFace, Legs, Activity, Cry, ConsolabilityPain Behavior ScaleRCTchildhoodchildrencoldcontrolled trialexternal coldnonpharmacologicalpediatric nursingpediatricsphlebotomyprocedural painrandomizedrandomized controlled trialstresstoddlervenipuncturevibration

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