Cobalt-Catalyzed Green Alkylations of Anilines with Tetrahydrofurans
Alexandra I Balalaeva1, Zechen Wu2, Evgeniya Podyacheva1,3
1A.N. Nesmeyanov Institute of Organoelement compounds of the Russian Academy of Sciences, Moscow, 119991, Russian Federation.
Abstract:
The use of bio-renewable resources as starting materials and reagents in synthetic chemistry is an important area for sustainable development. The use of tetrahydrofuran (THF) and 2-methyltetrahydrofuran (2-MeTHF) is reported, which can be obtained from lignocellulosic biomass, as potential alkylating agents for anilines. The developed N-alkylation process is catalyzed by the readily available cobalt salts and employs industrially available syngas as a reducing agent. The reported approach allows for the green and cost-effective production of N-alkylanilines from readily available feedstocks.
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