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Published on: February 14, 2011
Histoplasma capsulatum in wild mammals from Ecuador
Fernanda Hernández-Alomía1, Jorge Brito1, Ana Lucia Pilatasig2
1Instituto Nacional de Biodiversidad (INABIO), Quito, Ecuador.
Background:
Histoplasma capsulatum is a globally distributed dimorphic fungal pathogen endemic to the Americas, Africa, and Asia. It causes histoplasmosis, a disease acquired via inhalation of spores from contaminated environments. It thrives in nitrogen-rich soils and is disseminated by avian and chiropteran reservoirs. Histoplasma capsulatum has been found in wild mammals such as rodents, marsupials, felines, and xenarthrans, suggesting diverse reservoirs that may influence its maintenance and transmission in endemic areas. This study aimed to detect H. capsulatum in tissues of wild small mammals sampled across Ecuador.
Methods:
Tissue samples (n = 324) were collected from wild mammals across the Coast, Andean, and Amazon regions between 2022 and 2023. Species were identified morphologically and H. capsulatum was detected using nested PCR targeting the 100-kDa protein-encoding gene. Positive samples were sequenced and analyzed. Ecological niche modeling focused on environmental clustering, via one class support vector machine (OC-SVM) hypervolumes, identified regions suitable for fungal survival.
Results:
H. capsulatum was detected in 14% of samples in 30 of 106 species studied, predominantly in Chiroptera (80%) followed by Rodentia (15%) and Didelphimorphia (4%). Suitable environmental conditions were concentrated in Ecuador's Coast region with isolated patches in the Andean and Amazon regions.
Conclusion:
This study documents the broad host range and ecological distribution of H. capsulatum in Ecuador, reinforcing concerns about its zoonotic potential. The detection of the fungus across diverse mammalian taxa and ecosystems emphasizes the importance of wildlife-based surveillance to better understand fungal pathogen reservoirs and geographic hotspots.
Insights
Histoplasma capsulatum was found in 14% of wild mammals in Ecuador, primarily bats. This highlights the fungus
Area of Science:
- Mycology
- Infectious Diseases
- Ecology
Background:
- Histoplasma capsulatum is a dimorphic fungus causing histoplasmosis, endemic in the Americas, Africa, and Asia.
- It thrives in nitrogen-rich soils and is linked to avian and chiropteran reservoirs.
- Previous findings suggest diverse wild mammal reservoirs influence its transmission.
Purpose of the Study:
- To detect Histoplasma capsulatum in wild small mammals in Ecuador.
- To identify potential reservoirs and map suitable ecological niches for the fungus.
Main Methods:
- Collected 324 tissue samples from wild mammals across Ecuador's Coast, Andean, and Amazon regions (2022-2023).
- Identified species morphologically and used nested PCR targeting the 100-kDa gene for H. capsulatum detection.
- Employed ecological niche modeling (OC-SVM) to identify suitable fungal survival regions.
Main Results:
- Histoplasma capsulatum detected in 14% of samples across 30 species.
- Predominant detection in Chiroptera (80%), followed by Rodentia (15%) and Didelphimorphia (4%).
- Suitable environmental conditions were concentrated in Ecuador's Coast region, with some patches in Andean and Amazon regions.
Conclusions:
- This study confirms a broad host range and ecological distribution of H. capsulatum in Ecuador.
- Findings underscore the zoonotic potential and the importance of wildlife surveillance for fungal pathogens.
- Identified key regions and mammal taxa for understanding H. capsulatum reservoirs and transmission hotspots.
