Sex-Specific Factors Influencing GrimAge Acceleration in Middle-Aged Korean Adults
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View abstract on PubMed
Summary
This summary is machine-generated.Biological aging differs by sex in middle-aged adults. Lifestyle, inflammation, and hormonal factors influence GrimAge acceleration (GrimAA), a DNA methylation aging marker, with distinct drivers in men and women.
Area Of Science
- Gerontology
- Epigenetics
- Genomics
Background
- Middle-aged adults face sex-specific aging changes.
- Limited research exists on sex-specific biological aging factors.
- GrimAge acceleration (GrimAA) is a DNA methylation-based aging biomarker.
Purpose Of The Study
- Identify sex-specific factors influencing GrimAA in middle-aged Korean adults.
- Investigate lifestyle, clinical, and psychosocial predictors of biological aging.
Main Methods
- Utilized data from the Korean Genome and Epidemiology Study (KoGES) cohort (n=686).
- Calculated GrimAA using the GrimAge epigenetic clock from DNA methylation data.
- Employed hierarchical multiple regression for sex-specific analyses.
Main Results
- In men, GrimAA linked to smoking, drinking, inactivity, Hs-CRP, and HbA1C.
- In women, early menopause (<50 years) associated with higher GrimAA.
- Robust predictors of GrimAA: men (age, smoking, Hs-CRP); women (smoking, Hs-CRP).
Conclusions
- Sex differences in GrimAA stem from lifestyle, inflammation, and hormonal factors.
- Targeted, sex-specific interventions can mitigate biological aging acceleration.
- Understanding these determinants is crucial for healthy aging strategies.
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