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Updated: May 6, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
[Trends in case fatality of hemorrhagic stroke and ischemic stroke in China, 2015-2019]
1National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Insights
From 2015 to 2019, both hemorrhagic stroke (HS) and ischemic stroke (IS) case fatality rates within 28 days decreased in China. However, significant variations persist across stroke types, age groups, and urban-rural settings, necessitating targeted interventions.
Area of Science:
- Cardiovascular Epidemiology
- Neurology
- Public Health
Context:
- Stroke remains a leading cause of death and disability globally.
- Understanding epidemiological characteristics of stroke outcomes is crucial for public health interventions.
- China has a high burden of cardiovascular diseases, including stroke.
Purpose:
- To analyze the epidemiological features of 28-day case fatality for hemorrhagic stroke (HS) and ischemic stroke (IS) in China from 2015 to 2019.
- To identify trends and variations in stroke case fatality based on stroke subtype, age, and geographic location (urban vs. rural).
Summary:
- The study analyzed 28-day case fatality data for over 200,000 stroke deaths (HS and IS) across China between 2015 and 2019.
- While overall case fatality decreased significantly for both HS and IS, HS consistently had a higher fatality rate than IS.
- Higher fatality rates were observed in older age groups and rural areas for both stroke types, with notable differences in the magnitude of decrease between urban and rural populations.
Impact:
- The findings highlight a positive trend in reducing stroke mortality but underscore persistent disparities.
- Results indicate the need for tailored stroke prevention, treatment, and post-stroke management strategies in China.
- This research provides valuable data for public health policy and resource allocation to address the stroke burden effectively.
Abstract:
Objective: To present the epidemiological characteristics of ≤28 days case fatality in both hemorrhagic stroke (HS) and ischemic stroke (IS) patients in national cardiovascular disease surveillance areas from 2015 to 2019. Methods: Data on all new patients with stroke and ≤28 days outcomes from 2015 to 2019 were from the China Registry of Cardiovascular Events, which was established in 2014, covering 100 counties (cities, districts) in 31 provinces in China. Poisson regression was used to analyze the annual trend of ≤28 days case fatality. The age-standardized case fatality was directly calculated based on all new stroke onset. Results: In total, 112 069 deaths in HS patients ≤28 days after the onset, as well as 94 373 in IS patients, were identified during the study period. In 2019, the ≤28 days case fatality rate in HS patients was 4.75 times that of IS patients (37.08% vs. 7.80%), as well as that 4.06 times in urban areas (30.13% vs. 7.43%) and 5.30 times in rural areas (42.63% vs. 8.05%), respectively. Thus, in rural areas, HS patients showed 41.49% higher ≤28 days case fatality rate than that in urban areas, as well as 8.34% higher in IS patients. Those ≤28 days case fatality in both stroke subtypes onset increased with age and reached the highest level in those aged 85 years and over. During the study period, HS and IS patients in each age group displayed significant decrease trend in ≤28 days case fatality rate (trend P<0.001). Compared with that in 2015, the age-standardized ≤28 days case-fatality in HS patients in 2019 decreased by 28.52%, which was more in urban areas (-34.27%) than that in rural areas (-23.19%). Meanwhile, IS patients experienced a 39.90% reduction in ≤28 days case fatality, which was much lower in urban areas (-31.62%) than in rural areas (-45.10%, all trend P<0.001). Conclusions: From 2015 to 2019, ≤28 days case fatality in both HS and IS patients decreased in China. Wide variations of ≤28 days case-fatality were evident in the level and trend in stroke subtype, age of patients, as well as urban and rural areas. More precise and comprehensive strategies for stroke prevention, treatment, and post-stroke management are urgently required in China.
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