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Octodon degus: a natural animal model of aging and Alzheimer's disease

Michael J Hurley1,2, B Maximiliano Garduño3, Robert M J Deacon2

  • 1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

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|August 25, 2025
PubMed
Abstract

No abstract available in PubMed .

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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
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