Lichen Simplex Chronicus: Clinical Perspectives and Emerging Therapeutic Strategies.
Michal Moshkovich1, Luis F Andrade2, Mike Anderson3
1Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
American Journal of Clinical Dermatology
|August 26, 2025
Summary
Lichen simplex chronicus (LSC), or neurodermatitis, involves intense itching and skin thickening. Management requires individualized, multimodal plans addressing its physical and psychological impacts.
Area of Science:
- Dermatology
- Neuroimmunology
- Psychosomatic Medicine
Background:
- Lichen simplex chronicus (LSC), or neurodermatitis, is a chronic skin condition characterized by lichenified plaques from persistent scratching.
- It often stems from underlying triggers but presents a distinct clinical entity with significant morbidity, including sleep disruption and emotional distress.
Purpose of the Study:
- To provide a comprehensive review of the evolving understanding of LSC.
- To summarize current and emerging therapeutic strategies for managing LSC and its psychosocial burden.
Main Methods:
- Literature review synthesizing current data on LSC pathophysiology, diagnosis, and treatments.
- Exploration of established therapies (topical corticosteroids) and novel approaches (immunomodulators, neuromodulators, JAK inhibitors, biologics, procedural therapies).
Main Results:
- LSC pathogenesis involves neuroimmune pathways and type 2 inflammation.
- Therapeutic options range from topical agents to systemic treatments and procedural interventions.
- Individualized, multimodal treatment plans are crucial for optimizing patient outcomes.
Conclusions:
- Understanding LSC's neuroimmune basis informs targeted therapies.
- A multimodal approach is essential for managing LSC's complexity and improving quality of life.
- Addressing the psychosocial burden is integral to effective LSC patient care.
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