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Author Spotlight: Exploring Strategies for Successful Immune Response Against Tumors
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Single-cell multi-omics in cancer immunotherapy: from tumor heterogeneity to personalized precision treatment

Jiayuan Le1,2,3,4,5, Yating Dian1,2,3,4,5, Deze Zhao6

  • 1Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya road, Changsha, Hunan, 410008, China.

Molecular Cancer
|August 26, 2025
PubMed

Insights

Single-cell multi-omics technologies offer deep insights into cancer heterogeneity, improving cancer immunotherapy and personalized treatments. These advanced methods are crucial for precision oncology and overcoming treatment resistance.

Area of Science:

  • Oncology
  • Genomics
  • Immunology

Background:

  • Cancer immunotherapy has transformed oncology but faces challenges due to tumor complexity and heterogeneity.
  • Tumor heterogeneity within and between patients complicates personalized cancer treatment strategies.

Purpose of the Study:

  • To review advances in single-cell multi-omics technologies for dissecting tumor heterogeneity.
  • To highlight the impact of these technologies on cancer research, immunotherapy, and precision oncology.

Main Methods:

  • Single-cell sequencing technologies including genomics, transcriptomics, epigenomics, proteomics, and spatial omics.
  • Systematic examination of recent technological advancements and their applications in cancer research.

Main Results:

  • Single-cell multi-omics provide multi-layered insights into tumor biology and immune responses at single-cell resolution.
  • These technologies illuminate immune escape, treatment resistance, and enable neoantigen discovery.

Conclusions:

  • Single-cell multi-omics are revolutionizing precision oncology by enabling a deeper understanding of tumor heterogeneity.
  • These technologies are poised to become central to developing truly personalized cancer therapies and monitoring minimal residual disease.
Keywords:
ImmunotherapyPersonalized therapySingle-cell sequencingTumor heterogeneity

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