Related Experiment Video

Updated: Sep 10, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

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Atrial fibrillation and thromboembolic risk in hypertrophic cardiomyopathy

You-Jung Choi1,2, Neal K Lakdawala3

  • 1Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. flyiing48@gmail.com.

Journal of Cardiovascular Imaging
|August 26, 2025
PubMed

Insights

Atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) increases stroke risk. Advanced imaging and personalized treatments are crucial for managing thromboembolism in these patients.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Genetics

Background:

  • Atrial fibrillation (AF) is a common arrhythmia in hypertrophic cardiomyopathy (HCM).
  • Patients with HCM and AF face a significantly higher risk of thromboembolic events.
  • Traditional risk scores inadequately predict stroke risk in HCM due to disease-specific factors.

Purpose of the Study:

  • To review the epidemiology, pathophysiology, and clinical impact of AF and thromboembolism in HCM.
  • To explore advanced imaging techniques for assessing atrial remodeling and thromboembolic risk.
  • To discuss current and emerging management strategies for anticoagulation and stroke prevention.

Main Methods:

  • Literature review synthesizing current evidence.
  • Discussion of advanced imaging modalities: strain echocardiography, cardiac MRI, cardiac CT.
  • Analysis of anticoagulation strategies, direct oral anticoagulants, and adjunctive therapies.

Main Results:

  • Thromboembolic risk in HCM is influenced by unique structural, functional, and prothrombotic substrates.
  • Advanced imaging provides enhanced characterization of atrial changes and risk.
  • Current guidelines and evolving therapies offer options for stroke prevention.

Conclusions:

  • A multidisciplinary approach integrating advanced imaging and molecular profiling is essential.
  • Individualized management strategies are key to optimizing outcomes in HCM patients with AF.
  • Reducing the stroke burden in this high-risk population requires comprehensive care.

Keywords:
ArrhythmiasCardiacCardiomyopathiesIschemic stroke

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