Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

10.0K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
10.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COX-2 inhibition improves immune system homeostasis and decreases liver damage in septic rats.

The Journal of surgical research·2009
Same author

Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2009
Same author

3D-SURFER: software for high-throughput protein surface comparison and analysis.

Bioinformatics (Oxford, England)·2009
Same author

Total arch replacement with stented elephant trunk technique: a proposed treatment for complicated Stanford type B aortic dissection.

Journal of cardiac surgery·2009
Same author

Top-emitting white organic light-emitting devices with a one-dimensional metallic-dielectric photonic crystal anode.

Optics letters·2009
Same author

[Detection of tick and tick-borne pathogen in some ports of Inner Mongolia].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2009

Related Experiment Video

Updated: Sep 10, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

7.4K

Radioactive Iodine Therapy for Pediatric Graves' Hyperthyroidism.

Rui-Ting Hu1, Bin Li2

  • 1Department of Endocrinology, Hospital of Traditional Chinese Medicine of Linyi City, Linyi, Shandong, China.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|August 26, 2025
PubMed
Summary

Radioactive iodine (RAI) therapy for pediatric Graves

More Related Videos

Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

398
Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

916

Related Experiment Videos

Last Updated: Sep 10, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

7.4K
Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

398
Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

916

Area of Science:

  • Pediatric Endocrinology
  • Nuclear Medicine
  • Internal Medicine

Background:

  • Graves' hyperthyroidism (GH) is a common cause of pediatric hyperthyroidism.
  • Radioactive iodine (RAI) therapy is a primary treatment option for GH.
  • Understanding factors influencing RAI outcomes in children is crucial for effective management.

Purpose of the Study:

  • To determine the remission rate of RAI therapy in pediatric patients with GH.
  • To identify factors that predict successful remission after initial RAI treatment.
  • To inform treatment strategies for pediatric GH.

Main Methods:

  • Retrospective analysis of 44 pediatric patients with GH receiving their first RAI therapy.
  • Follow-up for 6 months post-treatment to assess outcomes.
  • Statistical analysis using SPSS 22.0, including logistic regression, to identify predictive factors.

Main Results:

  • The overall remission rate at 6 months was 52.3% (23/44).
  • Significant differences in disease duration, thyroid weight, and RAI dose were observed between remission and failure groups.
  • Logistic regression identified disease duration (>27 months) and thyroid weight (>50.17g) as key factors negatively impacting remission.

Conclusions:

  • Disease duration and thyroid weight significantly influence RAI therapy outcomes in pediatric GH.
  • Patients with longer disease duration or larger thyroids may require adjusted RAI dosing.
  • Higher RAI doses may be considered for pediatric patients with GH duration >27 months or thyroid weight >50.17g.