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Strain differences of ether susceptibility in mice.

K Kobayashi

    Jikken Dobutsu. Experimental Animals
    |October 1, 1985
    PubMed
    Summary

    Mouse strain differences in ether susceptibility were identified. C57BL/6 mice showed the highest resistance, while C3H/He mice were most sensitive to ether

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Genetics

    Background:

    • Ether is a common anesthetic agent.
    • Understanding strain-specific responses to anesthetics is crucial for research and clinical applications.
    • Genetic factors significantly influence anesthetic sensitivity in mice.

    Purpose of the Study:

    • To investigate and compare the susceptibility of six different mouse strains to the lethal effects of ether.
    • To determine the median lethal dose (LD50) and median effective dose (ED50) of ether in specific mouse strains.

    Main Methods:

    • Six mouse strains (C57BL/6, DBA/2, BALB/c, C3H/He, ICR, ddY) were exposed to varying concentrations of ether in air for 90 minutes.
    • Mortality rates were assessed to determine ether susceptibility.
    • LD50 and ED50 values were calculated for the most resistant (C57BL/6) and sensitive (C3H/He) strains.

    Main Results:

    • Significant differences in ether susceptibility were observed among the six mouse strains.
    • C57BL/6 mice exhibited the highest resistance to ether, while C3H/He mice were the most sensitive.
    • LD50 values for ether were higher in C57BL/6 mice (males: 6.0% atm, females: 6.6% atm) compared to C3H/He mice (males: 3.1% atm, females: 3.2% atm).
    • ED50 for loss of righting reflex was higher in male C57BL/6 mice than in male C3H/He mice.

    Conclusions:

    • Mouse strain genetics play a critical role in determining ether susceptibility.
    • C57BL/6 and C3H/He strains represent valuable models for studying genetic factors influencing anesthetic response.
    • These findings have implications for anesthetic use in research settings involving different mouse strains.

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