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Related Experiment Videos

[Pulmonary calcification in C3H mice].

M Yoshida, K Uchida, M Shigemura

    Jikken Dobutsu. Experimental Animals
    |October 1, 1985
    PubMed
    Summary

    Spontaneous pulmonary calcification occurs in aged female C3H mice. Pregnancy and lactation significantly worsen these lung lesions, which also appear in other organs.

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    Area of Science:

    • Pathology
    • Gerontology
    • Comparative Medicine

    Context:

    • Pulmonary calcification is a pathological process affecting various organs.
    • Age and reproductive status are known factors influencing disease incidence.
    • C3H mice serve as a model for studying age-related physiological changes.

    Purpose:

    • To investigate the incidence and severity of pulmonary calcification in C3H mice.
    • To determine the influence of age and reproductive history on pulmonary calcification.
    • To identify potential enhancing factors for spontaneous pulmonary calcification.

    Summary:

    • Pulmonary calcification was observed in aged female C3H mice, but not in young mice.
    • Lesions were more severe and frequent in aged breeding females compared to aged virginal females.
    • Calcified lesions were also found in the kidneys, heart, brain, ovaries, choroid plexus, cornea, and arteries.

    Impact:

    • This study identifies spontaneous pulmonary calcification in aged female mice.
    • Reproductive factors like pregnancy and lactation enhance the severity of pulmonary lesions.
    • The findings suggest a potential link between aging, reproduction, and systemic calcification in this mouse strain.

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