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Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

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Related Experiment Video

Updated: Sep 10, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Prognostic Factors in Sinonasal Cancers: A Multicenter Pooled Analysis.

Milica Stefanovic¹, Alberto Hernando-Calvo², Jesus Brenes Castro³

¹Radiation Oncology Department, Institut Català D'oncologia L'hospitalet.

The Laryngoscope

|August 26, 2025

Summary

Prognostic factors in non-metastatic sinonasal cancers (SNC) vary by histology. Mucosal melanoma and advanced tumor stage significantly increase mortality and distant metastasis risk in SNC patients.

Keywords:

chemotherapy head and neck cancer treatment radiotherapy sinonasal cancer squamous cell carcinoma trimodality treatment

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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

Area of Science:

Oncology
Head and Neck Surgery
Cancer Research

Background:

Sinonasal cancers (SNC) are a diverse group of malignancies with varying clinical outcomes.
Identifying specific prognostic factors is crucial for tailoring treatment strategies in non-metastatic (M0) SNC.

Purpose of the Study:

To identify key prognostic factors influencing survival and recurrence in patients with non-metastatic sinonasal cancers.
To analyze the impact of histology, tumor stage, and nodal status on locoregional failure, distant metastasis, and overall mortality.

Main Methods:

Retrospective review of electronic health records for 376 M0-SNC patients treated at two tertiary institutions.
Multivariable analysis (MVA) was employed to determine adjusted hazard ratios (aHR) for various prognostic factors.
p16 staining was performed for the squamous cell carcinoma (SCC) subset.

Main Results:

Histology significantly impacts outcomes: mucosal melanoma (MM), adenoid cystic carcinoma (ACC), and sinonasal undifferentiated carcinoma/neuroendocrine tumors (SNUC/SNEC) showed higher risks for distant metastasis.
Advanced tumor stage (T3-4) and nodal involvement were associated with increased risk of locoregional failure and mortality.
MM histology, older age, T3-4 tumors, and nodal involvement were linked to higher mortality risk.

Conclusions:

Different SNC histologies demonstrate distinct patterns of relapse and survival.
These findings underscore the necessity for individualized management strategies based on specific SNC histology and stage.