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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

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IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
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Accessory-pathway-mediated dilated cardiomyopathy in an infant.

Claire Bertail-Galoin1, Nabil Jbilou1, Victor Waldmann2

  • 1Felix Guyon Hospital Center, CHU La Réunion, Competence Center for Complex Congenital Heart Disease - M3C, Saint-Denis, France.

Cardiology in the Young
|August 26, 2025
PubMed
Summary
This summary is machine-generated.

A 10-month-old infant’s dilated cardiomyopathy was resolved by treating septal dyssynchrony caused by accessory pathway pre-excitation. Flecainide therapy normalized left ventricular function by eliminating pre-excitation.

Keywords:
accessory pathwaycardiomyopathyleft bundle branch blockpre-excitation

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Area of Science:

  • Pediatric Cardiology
  • Electrophysiology
  • Cardiomyopathy Research

Background:

  • Septal dyssynchrony can lead to dilated cardiomyopathy in infants.
  • Accessory pathways can cause cardiac electrical abnormalities.
  • Pre-excitation syndromes may manifest without overt tachycardia.

Purpose of the Study:

  • To describe a case of infant dilated cardiomyopathy linked to accessory pathway pre-excitation.
  • To investigate the impact of pre-excitation on septal synchrony and ventricular function.
  • To evaluate the efficacy of flecainide in managing this condition.

Main Methods:

  • Case report of a 10-month-old infant with dilated cardiomyopathy.
  • Electrocardiogram (ECG) analysis to identify pre-excitation and dyssynchrony.
  • Assessment of left ventricular function.
  • Therapeutic intervention with flecainide.

Main Results:

  • The infant presented with dilated cardiomyopathy attributed to left septal dyssynchrony from a right septal accessory pathway.
  • No atrioventricular reciprocating tachycardia was observed.
  • Flecainide therapy successfully eliminated antegrade pre-excitation on ECG.
  • Left ventricular function normalized following treatment.

Conclusions:

  • Accessory pathway-mediated pre-excitation can cause significant septal dyssynchrony and dilated cardiomyopathy in infants.
  • Early diagnosis and targeted antiarrhythmic therapy, such as flecainide, can reverse cardiac dysfunction.
  • This case highlights the importance of considering electrophysiological abnormalities in pediatric cardiomyopathy.