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Updated: Sep 10, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Structure-function relationship of S protein cleavage in cowpea mosaic virus intratumoral immunotherapy
Andrea Simms1,2,3,4, Jessica Fernanda Affonso de Oliveira1,2,3,4, Narek Minasov1,2,3,4
1Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA. nsteinmetz@ucsd.edu.
Abstract:
Translational studies are underway for cowpea mosaic virus (CPMV) as a candidate for intratumoral immunotherapy. To further strengthen the argument for translation, here we demonstrate that a structural deviation in CPMV's small (S) coat protein does not negatively impact its antitumor efficacy, immune cell uptake, or cytokine profile.
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