Related Experiment Video

Updated: Sep 10, 2025

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
10:24

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Published on: February 12, 2018

10.3K

Short-term outcomes of the PreserFlo MicroShunt in Japanese patients with exfoliation glaucoma: a comparison with

Teruki Yamae1, Rei Sakata2,3, Haruyuki Suzuki1

  • 1Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Japanese Journal of Ophthalmology
|August 26, 2025
PubMed
Abstract

Insights

The PreserFlo MicroShunt (PMS) effectively lowered intraocular pressure (IOP) in Japanese patients with exfoliation glaucoma (XFG) over six months. However, its efficacy was slightly less than in primary open-angle glaucoma (POAG) patients.

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Surgical Interventions

Background:

  • Exfoliation glaucoma (XFG) presents unique challenges in intraocular pressure (IOP) management.
  • The PreserFlo MicroShunt (PMS) is a surgical option for glaucoma, but its efficacy in specific populations like XFG requires evaluation.

Purpose of the Study:

  • To assess the safety and efficacy of initial PreserFlo MicroShunt (PMS) implantation in Japanese patients with exfoliation glaucoma (XFG).
  • To compare IOP control rates between XFG and primary open-angle glaucoma (POAG) patients using propensity score matching.

Main Methods:

  • A retrospective observational study involving 31 eyes of Japanese patients with XFG who underwent initial PMS implantation.
  • Evaluation of IOP, medication scores, and corneal endothelial cell density (CECD) up to 6 months post-surgery.
  • Kaplan-Meier analysis for 6-month survival rate and log-rank test for comparing XFG with matched POAG patients.

Main Results:

  • Significant IOP reduction from 22.3 mmHg to 14.7 mmHg and medication score decrease from 4.5 to 1.4 at 6 months.
  • A complete success rate of 48%; needling in 29.0% and additional surgery in 16.1% of eyes.
  • XFG patients showed higher postoperative IOP (14.8 mmHg) and medication scores compared to POAG patients.

Conclusions:

  • PreserFlo MicroShunt (PMS) implantation provides significant IOP reduction and a favorable safety profile in Japanese XFG patients.
  • Efficacy in XFG patients was slightly inferior to that observed in POAG patients.
  • Potential differences in PMS responsiveness between glaucoma subtypes warrant further investigation.
Keywords:
Exfoliation glaucomaIntraocular pressurePreserFlo MicroShuntPrimary open-angle glaucomaPropensity score matching

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.5K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.5K

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
561
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
674
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
749