Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

148
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
148
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

869
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
869
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

128
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
128
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

176
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
176
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

2.4K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.4K
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

256
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
256

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence and Predictors of Acute Pancreatitis in Patients With Diabetic Ketoacidosis (DKA) and Hyperosmolar Hyperglycemic State (HHS): A Multicenter Retrospective Study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same author

Mechanisms and clinical implications of gut-brain interactions.

The Journal of clinical investigation·2026
Same author

Identification of intestinal enteroendocrine cell subtypes and their associated hormones in zebrafish.

PLoS biology·2025
Same author

Loss of TRPV4 reduces pancreatic cancer growth and metastasis.

JCI insight·2025
Same author

Mutant p53 affects the mitochondrial proteome, promoting mitochondrial fragmentation and OXPHOS in pancreatic ductal adenocarcinoma cells.

The FEBS journal·2025
Same author

LRG1 inhibition promotes acute pancreatitis recovery by inducing cholecystokinin Type 1 receptor expression via Akt.

Theranostics·2025

Related Experiment Video

Updated: Sep 10, 2025

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

11.8K

Phosphate Improves Mitochondrial Function and Reduces Pancreatitis in Hypertriglyceridemia.

Nidula Mullappilly1, Sandip M Swain1, Joelle M-J Romac1

  • 1Department of Medicine, Duke University, North Carolina, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|August 26, 2025
PubMed
Summary
This summary is machine-generated.

Phosphate supplementation protects against hypertriglyceridemia-associated pancreatitis (HTGP). It corrects calcium imbalance and mitochondrial dysfunction, reducing pancreatic inflammation and injury in mice.

Keywords:
APOC3ATPhypertriglyceridemiahypophosphatemiamitochondriapancreatitis

More Related Videos

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.2K
High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
12:32

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

12.5K

Related Experiment Videos

Last Updated: Sep 10, 2025

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

11.8K
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.2K
High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
12:32

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

12.5K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Gastroenterology

Background:

  • Hypertriglyceridemia-associated pancreatitis (HTGP) is a significant cause of acute pancreatitis, but its underlying mechanisms remain unclear.
  • Hypophosphatemia, a state of low phosphate levels, is frequently observed in pancreatitis patients and linked to metabolic disorders and dyslipidemia.

Purpose of the Study:

  • To investigate the critical role of phosphate status in the development of HTGP.
  • To determine if phosphate supplementation can mitigate pancreatic injury in a hypertriglyceridemia mouse model.

Main Methods:

  • Utilized an APOC3 transgenic mouse model of hypertriglyceridemia.
  • Assessed pancreatic injury markers, including intra-acinar calcium levels, mitochondrial function, myeloperoxidase, and proinflammatory cytokines.
  • Evaluated the effects of phosphate supplementation on these markers and on caerulein-induced pancreatitis.

Main Results:

  • Hypertriglyceridemic mice showed pancreatic injury, elevated non-ER organelle calcium, impaired mitochondrial function, and increased inflammation.
  • Phosphate supplementation normalized calcium levels, restored mitochondrial function, and reduced inflammation and pancreatic injury.
  • Phosphate supplementation also lessened the severity of pancreatitis in mice on a low-phosphate diet under hypertriglyceridemic conditions.

Conclusions:

  • Phosphate plays a crucial protective role in the pancreas during hypertriglyceridemia.
  • Phosphate supplementation ameliorates HTGP by restoring calcium homeostasis and mitochondrial function, and by reducing inflammation.