Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

2.7K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
2.7K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

517
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
517
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

549
The pathophysiology of pneumonia involves the following steps:
549
Antimicrobial Proteins01:23

Antimicrobial Proteins

5.1K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
5.1K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

917
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
917
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Mucosal Type II Interferon Limits SARS-CoV-2 Replication in Humans.

medRxiv : the preprint server for health sciences·2026
Same author

How the Exposome Shapes Our Respiratory Health.

American journal of respiratory and critical care medicine·2026
Same author

Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes.

Science immunology·2026
Same author

Inhalation exposure to surrogate military burn pit emissions impairs systemic microvascular function: linking pulmonary insult and diverse peripheral responses.

Particle and fibre toxicology·2026
Same author

Analysis Of Salivary Herpesviruses Reveals Associations Between HHV-6 And Long COVID Severity.

medRxiv : the preprint server for health sciences·2026
Same author

A causal link between autoantibodies and neurological symptoms in long COVID.

Cell·2026

Related Experiment Video

Updated: Sep 10, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K

The role of complement in long COVID pathogenesis.

Rafael Bayarri-Olmos1,2,3, William Bain4,5, Akiko Iwasaki1,2,3

  • 1Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.

JCI Insight
|August 26, 2025
PubMed
Summary

Long COVID, a chronic condition after SARS-CoV-2 infection, involves diverse symptoms affecting daily life. Emerging evidence suggests complement system dysregulation may drive its pathology.

More Related Videos

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

7.1K
Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.4K

Related Experiment Videos

Last Updated: Sep 10, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K
A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

7.1K
Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.4K

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pathology

Background:

  • Long COVID is a chronic, multisystemic condition following SARS-CoV-2 infection.
  • It impacts daily function and work for at least 10% of infected individuals.
  • The underlying mechanisms of Long COVID remain poorly understood.

Purpose of the Study:

  • To review evidence linking complement system dysregulation to Long COVID.
  • To explore the role of the complement system in Long COVID pathogenesis.

Main Methods:

  • Literature review of recent studies.
  • Examination of research on immune response and disease pathology.

Main Results:

  • Recent studies suggest complement system dysregulation is implicated in Long COVID.
  • This dysregulation may be connected to coagulation, inflammation, and vascular injury.

Conclusions:

  • Complement system dysregulation is a potential contributor to Long COVID.
  • Further research is needed to fully elucidate its role in disease pathology.