HIV Removal by MOF-Based Microspheres: A Potential Adsorbent for Hemoadsorption.

Area of Science:

• Biomaterials Science
• Nanotechnology
• Virology

Background:

• Acquired Immunodeficiency Syndrome (AIDS) remains a critical global health challenge.
• Current treatments manage HIV but do not offer a cure.
• Hemoadsorption presents a potential strategy for viral clearance from blood.

Purpose of the Study:

• To develop and evaluate cellulose acetate/metal-organic framework (CA/MIL-125) composite beads as a viral hemoadsorbent for HIV.
• To assess the efficiency and mechanism of HIV adsorption by CA/MIL-125.
• To determine the blood compatibility and biocompatibility of the developed hemoadsorbent.

Main Methods:

• Fabrication of CA/MIL-125 composite beads using a one-step phase inversion method.
• Evaluation of the beads' surface area and pore structure.
• Assessment of HIV adsorption capacity and kinetics in plasma.
• Hemolysis, coagulation, and cytotoxicity tests to evaluate blood compatibility.

Main Results:

• CA/MIL-125 beads possess high specific surface area (221.17 m² g⁻¹) and interconnected macropores facilitating HIV transport.
• Achieved a 97.37% HIV adsorption rate in plasma, significantly higher than pure cellulose acetate.
• HIV adsorption followed pseudo-second-order kinetics and the Freundlich model, with a maximum adsorption capacity of 642.2 ng g⁻¹.
• Demonstrated good blood compatibility and biocompatibility.

Conclusions:

• CA/MIL-125 composite beads are effective viral hemoadsorbents for HIV.
• The MIL-125 component is crucial for the enhanced HIV adsorption capacity.
• This hemoadsorption strategy offers a promising new approach for AIDS treatment via hemoperfusion.