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Related Experiment Video

Updated: May 2, 2026

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
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Technical Description of eHealth Tools in an Environmental Exposure Chamber: Implementation Study.

Irene Garcia-Gutierrez1,2,3, Irene Dueñas-Requena4,5, Violeta Sanchez-Garcia4,6

  • 1Allergy Department, Marqués de Valdecilla University Hospital, Santander, Spain.

JMIR Formative Research
|August 26, 2025
PubMed
Summary

An integrated eHealth system successfully monitored allergic rhinitis symptoms in real-time during environmental exposure chamber challenges. This digital solution improved workflow and patient safety in allergen testing.

Keywords:
Power BIREDCapallergen challengeallergic rhinitisasthmaclinical data integrationdigital healthremote symptom monitoringrespiratory allergytelemedicine

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Area of Science:

  • Allergy and Immunology
  • eHealth and Digital Health
  • Clinical Research Technology

Background:

  • Environmental exposure chambers (EECs) offer controlled aeroallergen exposure for allergic rhinitis research.
  • Real-time, remote symptom monitoring within EECs presents significant challenges.
  • Standardized symptom assessment is crucial for reproducible allergic rhinitis studies.

Purpose of the Study:

  • To design, implement, and evaluate an integrated eHealth system for real-time clinical monitoring during EEC exposures.
  • To enhance workflow efficiency, data reliability, and patient safety in allergen challenge studies.
  • To leverage digital tools for streamlined data collection and remote patient observation.

Main Methods:

  • A prospective pilot study was conducted in a validated EEC using standardized grass pollen exposure.
  • 34 provocation tests were performed on allergic patients and nonallergic controls.
  • Data collection utilized REDCap for automated surveys (VAS, TNSS, TOSS, PEF, PNIF) and Power BI for real-time visualization.

Main Results:

  • 85% of allergic patients showed a positive response to allergen exposure, with a median Total Nasal Symptom Score (TNSS) of 6.
  • Mean exposure time for positive responders was 48.9 minutes, with early withdrawal based on symptom thresholds.
  • The integrated system enabled consistent, real-time symptom monitoring and successful data synchronization between REDCap and Power BI.

Conclusions:

  • The integrated eHealth system facilitated automated, real-time symptom tracking during EEC exposures.
  • This solution enhanced clinical oversight, supported timely decisions, and ensured patient safety.
  • The platform offers a flexible model for remote monitoring in allergen studies and other clinical settings.