Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Construction of conditional lod tables from multiple-locus linkage data.

C J MacLean, R Lew, S Yee

    Genetic Epidemiology
    |January 1, 1985
    PubMed
    Summary

    New conditional lod (c-lod) tables efficiently present multipoint linkage data, preserving gene order and genetic map information. This method aids in reconciling contradictory estimates from separate studies for conclusive genetic linkage analysis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neuropathological Evidence of Reduced Amyloid Beta and Neurofibrillary Tangles in Multiple Sclerosis Cortex.

    Annals of neurology·2025
    Same author

    A Keyword Approach to Finding Common Ground in Community-Based Definitions of Human Well-Being.

    Human ecology·2021
    Same author

    Pathogens associated with pleuritic pig lungs at an abattoir in Queensland Australia.

    Australian veterinary journal·2021
    Same author

    Diverse strains of Actinobacillus lignieresii isolated from clinically affected cattle in a geographically restricted area.

    Australian veterinary journal·2019
    Same author

    Flood protection ecosystem services in the coast of Puerto Rico: Associations between extreme weather, flood hazard mitigation and gastrointestinal illness.

    The Science of the total environment·2019
    Same author

    Genetic diversity and toxin gene distribution among serovars of Actinobacillus pleuropneumoniae from Australian pigs.

    Australian veterinary journal·2018

    Area of Science:

    • Genetics and Genomics
    • Bioinformatics
    • Statistical Genetics

    Background:

    • Multipoint linkage analysis is crucial for gene mapping but generating and presenting large datasets efficiently remains a challenge.
    • Existing methods for summarizing linkage data, such as standard lod tables, often result in significant information loss or are computationally intensive.
    • The need for standardized, informative, and data-efficient methods for presenting multipoint linkage data is critical for collaborative research.

    Purpose of the Study:

    • To develop an economical and efficient method for presenting multipoint linkage data.
    • To propose a novel lod table representation that preserves essential genetic information.
    • To facilitate the combination of data from multiple studies for robust genetic linkage and gene order determination.

    Related Experiment Videos

    Main Methods:

    • Introduction of conditional lods (c-lods), a new metric distinct from standard lod scores.
    • Calculation of c-lods for distances between adjacent loci, with optimization of all other locus distances.
    • Presentation of c-lods for n-1 adjacent pairs in an n-locus system, significantly reducing data volume.

    Main Results:

    • The proposed c-lod table representation preserves nearly all information on gene order and genetic map distance.
    • The sum of c-lods provides a close approximation to the true likelihood across the parameter space.
    • This method offers a substantial reduction in the data volume required for presentation compared to full likelihood tables.

    Conclusions:

    • Conditional lods offer an efficient and informative method for presenting multipoint linkage data.
    • C-lods are suitable for combining data from disparate studies, enabling reconciliation of varied recombination estimates.
    • This approach enhances the ability to achieve conclusive evidence for linkage and gene order through meta-analysis.