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Afterglow-driven tablet quality assessment: non-destructive detection via maltodextrin-based room temperature
Zhe Li1, Haolong Xiong1, Weifeng Zhu1
1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
International Journal of Pharmaceutics
|August 26, 2025
Summary
Maltodextrin
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Tablet quality control is crucial for drug efficacy and safety.
- Current non-destructive methods have limitations.
- Maltodextrin (MD) exhibits afterglow properties.
Purpose of the Study:
- To investigate maltodextrin's afterglow effect for non-destructive tablet quality detection.
- To explore the relationship between MD's phosphorescence and tablet properties like hardness and moisture content.
Main Methods:
- Fourier transform infrared spectroscopy (FTIR) for phosphorescence mechanism analysis.
- Preparation and testing of MD tablets for hardness, disintegration, and hygroscopicity.
- Measurement of phosphorescence lifetime and afterglow imaging.
- Assessment of content uniformity using MD mixed with other excipients.
Main Results:
- MD's hydroxyl groups facilitate phosphorescent emission.
- Phosphorescence lifetime of MD tablets is sensitive to humidity and hardness.
- Content uniformity detection showed significant differences in gray value standard deviations between uniform and non-uniform tablets.
Conclusions:
- Maltodextrin's afterglow is stimulus-responsive to moisture and hardness.
- This property enables non-destructive detection of tablet quality attributes.
- The findings support the development of novel non-destructive tablet quality control technologies.
