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Related Experiment Video

Updated: Sep 10, 2025

Ganglioside Extraction, Purification and Profiling
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Ganglioside profiling in neuroblastoma.

Manjul Pratap Singh1, Meenakshi Choudhary2, Anita Singh3

  • 1ABESIT College of Pharmacy, Ghaziabad, Uttar Pradesh 201002, India.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|August 26, 2025
PubMed
Summary

This study reviews methods for quantifying gangliosides in neuroblastoma cells, crucial for understanding pediatric cancer. Advances enhance analysis for biomarker discovery and treatment development.

Keywords:
Analytical techniquesBiomarker discoveryDrug developmentGangliosidesNeuroblastomaOmics integration

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Area of Science:

  • Biochemistry
  • Oncology
  • Analytical Chemistry

Background:

  • Gangliosides are vital in neuroblastoma (NB) research, influencing cell adhesion, proliferation, and signaling.
  • Quantifying NB cell gangliosides is key for identifying diagnostic targets and understanding disease mechanisms.

Purpose of the Study:

  • To analyze and review current methods for quantifying gangliosides in neuroblastoma cells.
  • To highlight advancements and challenges in ganglioside analysis for pediatric cancer research.

Main Methods:

  • Mass spectrometry (MS)
  • Nuclear magnetic resonance (NMR) spectroscopy
  • Fluorescence imaging
  • Immunoassays
  • Multidimensional chromatography
  • Imaging mass spectrometry

Main Results:

  • Advanced techniques improve sensitivity and comprehensiveness in ganglioside analysis.
  • Ganglioside analysis supports biomarker discovery, metabolism studies, and therapeutic development in neuroblastoma.

Conclusions:

  • Despite progress, challenges in method standardization, sample complexity, and data integration persist.
  • Interdisciplinary collaboration is essential to overcome limitations and advance neuroblastoma treatment through ganglioside insights.