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Updated: Sep 10, 2025

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
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The mechanisms and therapeutic role of nuclear factor, erythroid derived 2,-like 1 in cancers

Xuye Zhao1, Chenxi Zhan2, Yi Ding3

  • 1Queen Mary College, Jiangxi Medical College, Nanchang 330000, Jiangxi Province, China.

Cellular Signalling
|August 26, 2025
PubMed

Insights

Nuclear factor, erythroid derived 2,-like 1 (NFE2L1) influences cellular balance and has a complex role in cancer development and treatment. Understanding NFE2L1

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cellular Homeostasis

Background:

  • Nuclear factor, erythroid derived 2,-like 1 (NFE2L1) is a CNC-bZIP transcription factor.
  • It regulates cellular homeostasis, oxidative stress, and proteasome activity.
  • NFE2L1's role in tumorigenesis is complex and linked to oxidative stress and metabolic pathways.

Purpose of the Study:

  • To review the mechanisms of NFE2L1 in cancer development and progression.
  • To explore the therapeutic implications of NFE2L1 in cancer treatment.
  • To identify key unanswered questions for future research.

Main Methods:

  • Literature review of current evidence on NFE2L1.
  • Synthesis of findings on NFE2L1's molecular mechanisms.
  • Analysis of NFE2L1's role in cancer therapy.

Main Results:

  • NFE2L1 exhibits a dual role in tumor development.
  • Its functions are closely tied to oxidative stress, proteasome activity, and metabolic pathways.
  • NFE2L1 influences cancer therapy primarily through antioxidant and proteasome regulation.

Conclusions:

  • NFE2L1 is a critical factor in cancer biology with implications for therapy.
  • Further research is needed to fully elucidate NFE2L1's mechanisms and therapeutic potential.
  • Understanding NFE2L1's dual role is key for developing effective cancer treatments.
Keywords:
FerroptosisNFE2L1Oxidative stressProteasome homeostasisProteasome inhibitors

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