Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

235
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
235

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exceptional Long-Term Survival after Resection of Metachronous Liver and Lung Metastases Following Surgery for Pancreatic Cancer: A Case Report.

Surgical case reports·2026
Same author

A possible shared 4-6-week latency between MIS-C and Kawasaki disease: epidemiological insights from Japan.

Pediatric research·2026
Same author

Detection ability of model observer for diagnosis of active cardiac sarcoidosis on <sup>18</sup>F-FDG-PET.

Annals of nuclear medicine·2026
Same author

Fatal Injuries Caused by Falling Trees: Correlation Between Postmortem Computed Tomography and Forensic Autopsy Findings in Eight Cases.

International journal of legal medicine·2026
Same author

Eating-related distress in cancer cachexia: multicentre self-reported questionnaire study.

BMJ supportive & palliative care·2026
Same author

Immunological mechanism behind reactivated cryptococcosis in persistently infected mice following FTY720 treatment.

Infection and immunity·2026

Related Experiment Video

Updated: Sep 10, 2025

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

542

Optimization of Block Sequential Regularized Expectation Maximization Reconstruction Parameters for Striatal SPECT

Nao Yamaguchi1, Hayato Odagiri2,3, Hayato Sato1

  • 1Department of Diagnostic Image Analysis, Tohoku University Graduate School of Medicine, Miyagi, Japan.

Journal of Nuclear Medicine Technology
|August 26, 2025
PubMed
Summary
This summary is machine-generated.

Optimizing block sequential regularized expectation maximization (BSREM) for striatal SPECT imaging identified optimal noise-suppression (β) and edge-preservation (γ) parameter values for accurate diagnostic imaging.

Keywords:
123I-FP-CITSPECT/CT imagingblock sequential regularized expectation maximization methodring-type semiconductor SPECT/CT systemstriatal uptake ratio

More Related Videos

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.4K
Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

391

Related Experiment Videos

Last Updated: Sep 10, 2025

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

542
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.4K
Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

391

Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Radiochemistry

Background:

  • Striatal SPECT imaging is crucial for diagnosing neurological disorders.
  • The block sequential regularized expectation maximization (BSREM) method offers improved image reconstruction.
  • Optimizing BSREM parameters is essential for accurate quantitative analysis in SPECT.

Purpose of the Study:

  • To determine the optimal noise-suppression (β) and edge-preservation (γ) parameter values for BSREM reconstruction.
  • To evaluate image quality and diagnostic accuracy for 123I-labeled SPECT imaging of the striatum.
  • To establish optimal reconstruction settings for cadmium-zinc-telluride camera-based SPECT.

Main Methods:

  • A striatum phantom with varying 123I concentrations was used.
  • SPECT data were acquired using a cadmium-zinc-telluride camera and reconstructed with BSREM.
  • 42 images were generated by systematically varying β and γ values, followed by quantitative and visual assessment.

Main Results:

  • Increased β values reduced image noise (percent coefficient of variation).
  • Increased γ values enhanced image contrast (percent contrast).
  • Optimal parameter pairs (β=0.03, γ=5 and β=0.05, γ=10) provided diagnostically suitable images with accurate striatal tracer depiction.

Conclusions:

  • The study identified optimal β and γ values for BSREM reconstruction in striatal SPECT.
  • These optimized parameters ensure accurate visualization of tracer uptake in striatal regions.
  • The findings support improved diagnostic accuracy for neurological conditions using SPECT/BSREM.