Demographic and Clinicopathologic Characteristics of 3723 Patients with Primary Oral Squamous Cell Carcinoma: A Consecutive, Single-Center Study Over 11 Years (2012-2023)
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View abstract on PubMed
Summary
This summary is machine-generated.Oral squamous cell carcinoma (OSCC) predominantly affects males, with the tongue being the most common site. Alcohol consumption, age over 50, and perineural invasion are key risk factors for advanced OSCC.
Area Of Science
- Oncology
- Oral Medicine
- Public Health
Background
- Oral squamous cell carcinoma (OSCC) is a significant global health concern.
- Understanding its demographic and clinicopathological profile is crucial for effective management.
Purpose Of The Study
- To investigate the demographic and clinicopathologic characteristics of OSCC.
- To identify risk factors associated with advanced pathological TNM (pTNM) stage in OSCC.
Main Methods
- Retrospective analysis of 3723 OSCC patients from 2012-2023.
- Demographic, clinicopathological, and treatment data were analyzed.
- Statistical methods included Mann-Whitney U, Chi-square, Fisher's exact, and logistic regression.
Main Results
- OSCC predominantly affected males (2.35:1 ratio) aged 45-59 years, primarily in Hubei Province, China.
- The tongue body was the most common site; 41.2% presented with locally advanced disease (pTNM stage III/IV).
- Alcohol consumption, age >50 years, and perineural invasion (PNI) were independent risk factors for advanced OSCC.
Conclusions
- OSCC is more prevalent in males, frequently occurring on the tongue.
- Alcohol, older age, and PNI are significant risk factors for advanced OSCC.
- Future research should address single-center bias and explore OSCC heterogeneity to improve prevention.
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