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Related Experiment Videos

Normal human endometrium. An ultrastructural survey.

F J Cornillie, J M Lauweryns, I A Brosens

    Gynecologic and Obstetric Investigation
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    This review details the cyclic ultrastructural changes in endometrial cells and microvasculature, particularly in infertile patients. It highlights cellular involution and stromal cell functions in endometrial clearance.

    Area of Science:

    • Reproductive biology
    • Cellular and molecular biology
    • Gynecology

    Background:

    • Endometrial cyclic changes are crucial for reproductive success.
    • Understanding ultrastructural alterations is key to diagnosing infertility.
    • Endometriosis and tubal dysfunction impact endometrial receptivity.

    Purpose of the Study:

    • To provide an ultrastructural review of cyclic changes in endometrial cells and microvasculature.
    • To correlate these changes with infertility in patients with endometriosis or tubal dysfunction.
    • To elucidate the functional significance of observed cellular phenomena.

    Main Methods:

    • Review of ultrastructural changes in endometrial biopsies.
    • Analysis of surface and glandular epithelial cells.

    Related Experiment Videos

  • Examination of stromal cells and stromal microvasculature.

    • Main Results:

    • Detailed description of epithelial cell development during the proliferative and secretory phases.
    • Identification of the postovulatory triad (glycogen, nuclear channels, giant mitochondria) and its function.
    • Characterization of premenstrual cellular involution, including apoptosis and lysosomal activity.
    • Demonstration of stromal cell secretory, remodeling, macropinocytotic, and phagocytotic functions.
    • Hypothesized endometrial clearance mechanism involving stromal cells and blood-derived phagocytes via fenestrated capillaries.

    Conclusions:

    • Stromal cell proteolytic activities and phagocytes are crucial for endometrial clearance in the absence of superficial lymphatics.
    • Fenestrated endometrial blood capillaries may facilitate tissue fluid drainage.
    • Ultrastructural analysis provides insights into endometrial function and dysfunction in infertility.