Related Experiment Video
Updated: Sep 10, 2025
09:30
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
11.4K
Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal
Guichun Wang1, Yuxiao Wang1, Yang Ding1
1College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 27, 2025
Summary
A novel hydrogel system (HQUP@TF127) combats periodontitis by targeting bacteria, reducing oxidative stress, and promoting tissue regeneration. This advanced material enhances drug delivery for effective treatment of this complex inflammatory disease.
Area of Science:
- Biomaterials Science
- Periodontology
- Regenerative Medicine
Background:
- Periodontitis is a complex inflammatory disease characterized by pathogenic biofilms, oxidative stress, and poor tissue regeneration.
- Effective periodontitis treatment is hindered by the oral environment's dynamic nature, limiting drug retention and efficacy.
Purpose of the Study:
- To develop a multifunctional hydrogel system (HQUP@TF127) for treating periodontitis.
- To address challenges in drug delivery and enhance therapeutic outcomes for periodontitis.
Main Methods:
- Development of a triple-functional hydrogel system (HQUP@TF127) incorporating an antibacterial agent (4-terpineol) and an anti-inflammatory/osteogenic ingredient (quercetin).
- Utilized hollow mesoporous silica nanoparticles with a ROS-responsive gatekeeper for controlled quercetin release.
- Incorporated thermosensitive Pluronic F127 for prolonged drug retention and deep pathogen eradication.
- Evaluated HQUP@TF127 in a rat model of periodontitis, assessing its impact on inflammation, bone regeneration, and stem cell activity.
Main Results:
- HQUP@TF127 demonstrated antibacterial properties, ROS scavenging, and enhanced tissue regeneration.
- Controlled release of quercetin and prolonged retention of 4-terpineol improved therapeutic efficacy.
- Restored endoplasmic reticulum homeostasis and maximized osteogenic potential of periodontal ligament stem cells.
- In vivo studies showed suppressed osteoclast activation, reduced inflammation, and increased bone mineral density and periodontal tissue regeneration.
Conclusions:
- The developed HQUP@TF127 hydrogel system effectively addresses the multifactorial pathology of periodontitis.
- The system overcomes local drug administration obstacles through synergistic mechanisms and improved drug delivery.
- HQUP@TF127 shows significant potential for periodontitis treatment, warranting further translational research.
