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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
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Nanocarrier-Based Systems for Targeted Delivery: Current Challenges and Future Directions.
Zichen Xu1, Yongyi Xie2, Wenjie Chen2
1School of Biomedical Engineering University of Technology Sydney Ultimo NSW Australia.
Medcomm
|August 27, 2025
Summary
Nanomaterials offer advanced drug and gene delivery with tunable properties for better treatment. However, achieving precise nuclear targeting remains a challenge, requiring further research for clinical translation in nanomedicine.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacology
Background:
- Nanomaterials are advanced platforms for drug and gene delivery.
- Nanocarriers offer improved pharmacokinetics and therapeutic performance.
- Diverse nanocarrier systems (lipid-based, polymer-based, hybrid) are under development.
Purpose of the Study:
- Review recent advances in nanocarrier design for targeted delivery.
- Focus on strategies for precise nuclear targeting.
- Assess challenges and opportunities in nanomedicine translation.
Main Methods:
- Exploration of passive targeting strategies (size, morphology, charge modulation).
- Analysis of active targeting strategies (nuclear localization signals, ligands).
- Comprehensive assessment of current literature on nanocarrier applications.
Main Results:
- Nanocarriers show promise in preclinical studies for targeted delivery.
- Significant challenges persist in achieving specific tissue, cellular, and intracellular delivery.
- Nuclear targeting strategies are advancing through passive and active approaches.
Conclusions:
- Targeted nanocarriers are crucial for precision nanomedicine.
- Overcoming limitations in delivery efficiency and off-target effects is vital for clinical translation.
- Further research is needed to fully realize the potential of nanomedicine for enhanced therapeutic outcomes.
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