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Optimizing tDCS parameters for post-stroke upper limb recovery: a systematic review and meta-analysis protocol.

Cui Liu1, Wei Wang1, Chen-Qi Zhang2

  • 1Department of Rehabilitation Medicine, Suining Central Hospital, Suining City, Sichuan Province, China.

International Journal of Surgery Protocols
|August 27, 2025
PubMed
Summary

This meta-analysis evaluates transcranial direct current stimulation (tDCS) for stroke survivors. It aims to identify optimal tDCS parameters to improve upper limb motor function and guide clinical rehabilitation protocols.

Keywords:
meta-analysisneurorehabilitationstroketranscranial direct current stimulation (tDCS)upper limb motor impairments

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Medical Technology

Background:

  • Stroke is a major global cause of death and disability, frequently leading to upper limb motor impairments.
  • Transcranial direct current stimulation (tDCS) shows promise for post-stroke recovery, but its effectiveness and optimal parameters are debated.
  • Heterogeneous findings necessitate a systematic evaluation of tDCS parameters for upper limb motor function in stroke patients.

Purpose of the Study:

  • To systematically evaluate the effects of various transcranial direct current stimulation (tDCS) parameters on upper limb motor impairments in stroke patients.
  • To provide evidence-based guidance for selecting optimal tDCS stimulation parameters for stroke rehabilitation.
  • To synthesize current literature through a meta-analysis to clarify tDCS efficacy.

Main Methods:

  • Comprehensive literature search of multiple databases (MEDLINE, Cochrane, Web of Science, Embase, CNKI, Wanfang) up to December 31, 2024.
  • Inclusion of randomized controlled trials (RCTs) involving adult stroke patients receiving tDCS interventions.
  • Analysis of primary outcomes (upper limb motor function scores) and secondary outcomes (activities of daily living, adverse events) using Stata 16.0.

Main Results:

  • The study will elucidate the impact of different stimulation parameters, including current density, duration, and target location, on therapeutic outcomes.
  • It aims to provide the most current evidence and recommendations for optimal tDCS intervention selection.
  • The meta-analysis will quantify the effects of tDCS on upper limb motor function.

Conclusions:

  • Transcranial direct current stimulation (tDCS) holds significant potential for enhancing upper limb motor function in stroke survivors.
  • This research will offer crucial insights into optimizing tDCS parameters for improved therapeutic outcomes.
  • Findings are expected to encourage the broader integration of tDCS into clinical stroke rehabilitation strategies.