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60-Day Peripheral Nerve Stimulation in Chronic Knee Pain: A Retrospective Analysis
Jamal Hasoon1, Alexander Rothkrug2, Grant H Chen1
1Department of Anesthesiology, Critical Care, and Pain Medicine The University of Texas Health Science Center at Houston.
Orthopedic Reviews
|August 27, 2025
Summary
Peripheral nerve stimulation (PNS) effectively treated chronic knee pain in a 60-day study. Most patients experienced significant pain relief compared to conventional medical management (CMM).
Area of Science:
- Pain Management
- Neurology
- Medical Devices
Background:
- Chronic knee pain is a growing concern, causing significant functional limitations and reduced quality of life.
- Peripheral nerve stimulation (PNS) offers an alternative approach by using electrical impulses to block pain signals.
- Conventional medical management (CMM) is the standard treatment for chronic knee pain.
Purpose of the Study:
- To evaluate the effectiveness of a 60-day peripheral nerve stimulation (PNS) system for chronic knee pain.
- To compare the outcomes of PNS therapy with conventional medical management (CMM).
- To assess patient response defined as ≥ 50% pain relief.
Main Methods:
- Retrospective database and chart review of patients treated for chronic knee pain.
- Analysis of 18 patients receiving a 60-day percutaneous PNS therapy.
- Comparison with a control group of 12 patients receiving CMM.
Main Results:
- 94.4% of patients (17/18) undergoing PNS achieved ≥ 50% pain relief.
- The average pain relief among PNS responders was 82.3%.
- Only 33.3% of patients in the CMM group met the responder threshold.
Conclusions:
- A 60-day percutaneous PNS system is effective in managing chronic knee pain.
- PNS demonstrates superior efficacy compared to CMM for knee pain relief.
- Further research is warranted to explore long-term efficacy for various pain conditions.

