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Achieving a rapid and continuous learning health system requires socio-technical harmonization of research and
Cong Liu1, Casey N Ta2, Elisabeth S DiMaria3
1Department of Pediatrics, Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02445 USA.
Abstract:
This perspective identifies challenges in integrating clinical research and care delivery in a rapid and continuous Learning Health System (LHS), focusing on Information technology (IT) systems and workforce harmonization. Based on our experiences, we analyzed differences in funding mechanisms, governance, regulatory frameworks, priorities, workforce culture, technology architecture, risk tolerance, and data standardization. We highlight significant barriers to the LHS implementation caused by IT misalignment between clinical research and patient care and propose strategies to overcome these challenges.
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