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Lung epithelioid hemangioendothelioma
Wala Ben Kridis1, Mahmoud Hakim1, Dhouha Sakka1
1Department of Medical Oncology, Habib Bourguiba Hospital, University of Sfax, 3029 Sfax, Tunisia.
Indian Journal of Thoracic and Cardiovascular Surgery
|August 27, 2025
Summary
Lung epithelioid hemangioendothelioma (LEHE) is a rare vascular tumor. Histopathology, including ERG and CD31 staining, is crucial for accurate LEHE diagnosis and avoiding misdiagnosis.
Area of Science:
- Oncology
- Pathology
- Vascular Biology
Background:
- Lung epithelioid hemangioendothelioma (LEHE) is an uncommon vascular neoplasm.
- LEHE exhibits low to intermediate malignant potential.
- Accurate diagnosis is essential due to its rarity and potential for misinterpretation.
Purpose of the Study:
- To report a case of LEHE in a non-smoker.
- To emphasize the diagnostic role of histopathology and specific biomarkers.
- To highlight the importance of avoiding misdiagnosis in LEHE.
Main Methods:
- Histopathological examination of lung tissue.
- Immunohistochemical staining for specific markers.
- Clinical case presentation and analysis.
Main Results:
- Diagnosis of LEHE confirmed via histopathology.
- Positive staining for erythroblast transformation-specific-related gene (ERG).
- Positive staining for cluster of differentiation 31 (CD31).
Conclusions:
- Histopathological diagnosis is definitive for LEHE.
- ERG and CD31 are valuable markers in LEHE diagnosis.
- Timely and accurate diagnosis prevents misclassification and guides appropriate management.
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