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Related Concept Videos

Precipitation Processes01:12

Precipitation Processes

584
The experimental conditions in a gravimetric analysis should be optimized to maximize the particle size and purity of the obtained precipitate. Ideally, the concentration of the precipitating reagent should be low with effective stirring to maintain low relative supersaturation for the growth of large crystals. In homogeneous precipitation, the precipitant is slowly generated by a chemical reaction in the solution to avoid local reagent excesses. For example, urea decomposes gradually to...
584
Precipitate Formation and Particle Size Control01:16

Precipitate Formation and Particle Size Control

947
In precipitation gravimetry, the precipitating agent should react specifically or selectively with the analyte. While a specific reagent reacts with the analyte alone, a selective reagent can react with a limited number of chemical species.
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...
947

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Related Experiment Video

Updated: Sep 10, 2025

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

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Process and Formulation Parameters Governing Polymeric Microparticle Formation via Sequential NanoPrecipitation

Parker K Lewis1, Nouha El Amri1, Erica E Burnham1

  • 1Department of Chemical and Biomolecular Engineering, Tandon School of Engineering, New York University, Brooklyn 11201, United States.

ACS Engineering Au
|August 27, 2025
PubMed
Summary

Sequential NanoPrecipitation (SNaP) offers precise control over polymeric microparticle (MP) production, bridging the gap between lab precision and industrial scalability for drug delivery applications.

Keywords:
continuous flow manufacturingdrug deliverymicroparticlepolymer microparticlesequential nanoprecipitation

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Pharmaceutical Sciences

Background:

  • Polymeric microparticles (MPs) are crucial for extended-release drug delivery.
  • Current manufacturing methods struggle to balance precise size control with industrial scalability.

Purpose of the Study:

  • To introduce and evaluate Sequential NanoPrecipitation (SNaP) as a scalable method for producing polymeric MPs.
  • To investigate critical process parameters for controlling MP size and polydispersity.

Main Methods:

  • Systematic investigation of poly-(lactic acid) (PLA) MPs stabilized with poly-(vinyl alcohol) (PVA).
  • Comparison of vortex and impinging jet mixing geometries.
  • Analysis of delay time and core stream concentration effects on particle formation.
  • Encapsulation of itraconazole and assessment of release profiles.

Main Results:

  • Vortex mixing demonstrated superior core assembly, especially at higher concentrations.
  • Microparticle assembly followed diffusion-limited growth kinetics.
  • Achieved precise control over microparticle size (1.6-3.0 μm) with narrow polydispersity.
  • Demonstrated versatility with different stabilizers and successful drug encapsulation (83-85% efficiency).

Conclusions:

  • SNaP is a robust and scalable platform for producing high-quality pharmaceutical microparticles.
  • The method provides superior control over critical quality attributes for drug delivery systems.