Related Experiment Video
Updated: Sep 10, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Characterising high-order interdependence via entropic conjugation
Fernando E Rosas1,2,3,4, Aaron J Gutknecht5, Pedro A M Mediano6,7
1Sussex AI and Sussex Centre for Consciousness Science, Department of Informatics, University of Sussex, Brighton, UK.
Abstract:
High-order phenomena are pervasive across complex systems, yet their formal characterisation remains a formidable challenge. The literature provides various information-theoretic quantities that capture high-order interdependencies, but their conceptual foundations and mutual relationships are not well understood. The lack of unifying principles underpinning these quantities impedes a principled selection of appropriate analytical tools for guiding applications. Here we introduce entropic conjugation as a formal principle to investigate the space of possible high-order measures, which clarifies the nature of the existent high-order measures while revealing gaps in the literature. Additionally, entropic conjugation leads to notions of symmetry and skew-symmetry which serve as key indicators ensuring a balanced account of high-order interdependencies. Our analyses highlight the O-information as the unique skew-symmetric measure whose estimation cost scales linearly with system size, which spontaneously emerges as a natural axis of variation among high-order quantities in real-world and simulated systems.
Related Concept Videos
Entropy Change in Reversible Processes
The statement can be further generalized to prove that entropy is a state function. Take a cyclic process between any two points on a p-V diagram.
Entropy and Solvation
Entropy and the Second Law of Thermodynamics
The relation between entropy and disorder can be illustrated with the example of the phase change of ice to water. In ice, the molecules are located at specific sites giving a solid state, whereas, in a liquid form, these molecules are much freer to move. The molecular arrangement has therefore become more randomized. Although the change in average...
Structure of Conjugated Dienes
Conjugated dienes are compounds characterized by the presence of alternating double and single bonds. In a conjugated system like 1,3-butadiene, the unhybridized 2p orbital on each carbon overlaps continuously, allowing the π electrons to be delocalized across the entire molecule. In contrast, this type of overlap does not occur in cumulated and isolated dienes, such as 2,3-pentadiene and 1,4-pentadiene, respectively. Instead, the π electrons remain localized between the double...
Entropy
When an ideal gas expands isothermally, the disorder in the gas increases. From the molecular perspective, the gas molecules have more volume to move around in.
Consider an infinitesimal step in the expansion, which...
Stability of Conjugated Dienes
A comparison of the enthalpies of hydrogenation of dienes reveals that conjugated dienes release less heat on hydrogenation, rendering them more stable than their nonconjugated analogs.

