I2-DMSO mediated multi-component cascade cyclization to construct pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine-6-one
Yu-Man Song1, Li-Sheng Wang1, You Zhou1
1State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University Wuhan Hubei 430079 China chwuax@mail.ccnu.edu.cn.
Abstract:
A one-pot synthesis of the pyrazolo[3,4-b]pyrrolo[3,4-d]pyridin-6-one skeleton has been developed using aryl methyl ketones, 3-aminopyrazoles, and enaminamides as substrates. This method features metal-free catalysis and broad substrate compatibility (36 examples). The reaction involves the formation of two C-C and two C-N bonds, while constructing a tetrasubstituted carbon stereocenter bearing a reactive hydroxyl group.
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