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Sample Ascertainment and Recruitment Sources in the Accelerating Medicines Partnership Schizophrenia Program
Jean Addington1, Amy Shalev1, Lu Liu1
1Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, T2N 4Z6, Canada.
Schizophrenia Bulletin Open
|August 27, 2025
Summary
Self-referral is the primary recruitment source for clinical high-risk (CHR) and community controls (CC) in the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program. Understanding these diverse recruitment channels is key for future schizophrenia research.
Area of Science:
- Psychiatry
- Neuroscience
- Clinical Psychology
Background:
- The Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program aims to investigate clinical variables and biomarkers in individuals at clinical high-risk (CHR) for psychosis and community controls (CC).
- The study involved a large cohort of 2040 CHR and 652 CC participants.
Purpose of the Study:
- To identify and analyze the diverse recruitment sources utilized for the AMP SCZ program.
- To understand the characteristics of participants based on their recruitment pathways.
- To inform future strategies for recruiting participants in psychosis research.
Main Methods:
- Data on recruitment sources were available for 1640 CHR and 514 CC participants.
- Participants were assessed using the Positive Symptoms and Diagnostic Criteria for the Comprehensive Assessment of At-Risk Mental States Harmonized with the SIPS (SIPS) for CHR criteria and attenuated psychotic symptoms (APSs).
- Social functioning was measured using the Global Functioning: Social Scale.
Main Results:
- Self-referral was the most common recruitment source for both CHR and CC participants across 13 identified sources.
- Participants recruited via self-referral were generally older, with less severe APS and higher social functioning compared to other groups.
- Individuals recruited from adult community mental health services exhibited poorer functioning and more severe APS.
Conclusions:
- The study highlights the significant role of self-referral, particularly in North America, potentially reflecting evolving help-seeking behaviors influenced by digital media.
- Understanding the patterns and characteristics associated with different recruitment sources is crucial for optimizing participant recruitment in future CHR and schizophrenia studies.
- Regional variations in recruitment strategies were observed, emphasizing the need for tailored approaches in global research initiatives.
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