Sporadic Fundic Gland Polyposis Associated With Long-Term Proton Pump Inhibitor Use: A Case Report

Fundic gland polyps (FGPs) are the most common type of gastric polyps and are frequently discovered incidentally during upper endoscopy. Long-term use of proton pump inhibitors (PPIs) has been associated with an increased risk of developing FGPs. We present a case of PPI-induced FGP in a 78-year-old woman who had been taking omeprazole daily for 15 years and was referred for evaluation of anemia. Gastroscopy revealed innumerable FGPs in the gastric body. Histological analysis demonstrated dilated glands within the fundic mucosa, consistent with FGPs. These polyps are typically small and benign and located in the gastric corpus and fundus. While FGPs are generally non-neoplastic, discontinuation of PPI therapy should be considered on a case-by-case basis. Indications for long-term PPI use should be regularly assessed. Unnecessary PPI therapy should be discontinued when appropriate.