Related Experiment Video

Updated: Sep 10, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K

Predictive Role of CX3CL1 and D-dimer Levels in Mortality Risk Stratification for COPD Patients With COVID-19

Jing Xue1, Meimei Liu2, Xin Liu2

  • 1Department of Internal Medicine, Jingbian County Hospital of Traditional Chinese Medicine, Yulin, CHN.

Cureus
|August 27, 2025
PubMed

Insights

Elevated levels of CX3CL1 and D-dimer predict mortality in hospitalized patients with chronic obstructive pulmonary disease (COPD) and COVID-19. Monitoring these inflammatory biomarkers can improve clinical decisions and patient outcomes.

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Immunology

Background:

  • Chronic obstructive pulmonary disease (COPD) exacerbations increase susceptibility to infections.
  • COVID-19 poses a significant threat to patients with underlying respiratory conditions like COPD.
  • Identifying predictors of mortality in COPD patients with COVID-19 is crucial for effective management.

Purpose of the Study:

  • To investigate the predictive value of CX3CL1 and D-dimer for mortality in hospitalized COPD patients with COVID-19.
  • To explore the association between inflammatory biomarkers and disease severity in this patient cohort.

Main Methods:

  • Retrospective study at Yulin Hospital, analyzing data from hospitalized COPD patients with COVID-19.
  • Collected complete blood counts and inflammatory cytokine levels at admission.
  • Assessed the relationship between CX3CL1, D-dimer, and mortality.

Main Results:

  • CX3CL1 and D-dimer levels were significantly higher in critical illness participants compared to severe cases.
  • CX3CL1 (0.78) and D-dimer (0.68) showed strong predictive indices.
  • Elevated CX3CL1 and D-dimer were associated with prolonged illness in COPD patients with COVID-19.

Conclusions:

  • CX3CL1 and D-dimer are potential biomarkers for predicting mortality in severe COVID-19 patients with COPD.
  • Monitoring these biomarkers can aid in clinical decision-making and risk stratification.
  • Improved risk assessment may lead to more targeted and effective treatment strategies.
Abstract

Keywords:
copd: chronic obstructive pulmonary diseasecovid-19cx3cl1d-dimermortality

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.5K

Related Concept Videos

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
517
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
119
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.9K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
55
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.9K