Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Metallic Solids

Metallic Solids

Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability. Many...

Colloidal precipitates

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...

Types of Reversible Electrodes

Types of Reversible Electrodes

For electrode reversibility to be maintained, all the reactants and products involved in the half-reaction must be present at the electrode. There are several types of reversible electrodes (half-cells).In metal-metal-ion electrodes, a metal balances electrochemically with a solution of its own ions. Examples are Cu2+|Cu and Zn2+|Zn. Metals that react with the solvent, like group 1 and most group 2 metals, which react with water, and zinc, which reacts with aqueous acidic solutions, cannot be...

The Electrical Double Layer

The Electrical Double Layer

In the region where two bulk phases meet, an intricate electric charge distribution arises due to charge transfer, ion adsorption, molecular orientation, and charge distortion. This complex distribution is commonly referred to as the electrical double layer.When a solid electrode interfaces with ions in an electrolyte solution, the speed of electron transfer dictates the rates of oxidation and reduction. The electrode acquires a charge through the escape of atoms into the solution as cations or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ion-Specific Modulation of Ferri/Ferrocyanide-Driven Gold Dissolution Uncovered by Quantitative Quartz Crystal Microbalance Analysis.

Analytical chemistry·2026

Same author

Toward Breath-Based Diagnostics via Water-Mediated Capture of Synthetic Breath Biomarkers in SERS-Active Plasmonic Nanogaps.

Nano letters·2026

Same author

Functional Design and Biophysical Characterization of Analyte-Responsive Polymers.

Biomacromolecules·2025

Same author

Technology and Continuous Glucose Monitoring Access, Literacy, and Use Among Patients at the Diabetes Center of an Inner-City Safety-Net Hospital: Mixed Methods Study.

JMIR diabetes·2024

Same author

An Orthogonal Workflow of Electrochemical, Computational, and Thermodynamic Methods Reveals Limitations of Using a Literature-Reported Insulin Binding Peptide in Biosensors.

ACS omega·2024

Same author

Understanding the Phase Behavior of a Multistimuli-Responsive Elastin-like Polymer: Insights from Dynamic Light Scattering Analysis.

The journal of physical chemistry. B·2024

Same journal

Improved Microplastic Identification from Simultaneously Collected Photothermal Infrared and Raman Spectra Using Multiview Conformal Prediction.

ACS measurement science au·2026

Same journal

Rapid Classification of Coffee Varieties Using Single-Bean Hot Gas Extraction Ion-Mobility Spectrometry with Machine Learning.

ACS measurement science au·2026

Same journal

Data-Driven Electrochemistry Reveals the Impact of Hydrophobicity on Aptamer Cross-Reactivity.

ACS measurement science au·2026

Same journal

Selective Preconcentration and Mass Spectrometry Profiling of Charged Extracellular Modified Ribonucleosides by Borate Complexation and Temperature-Assisted Ionic Liquid Microextraction.

ACS measurement science au·2026

Same journal

Transformation-Aware Molecular Networking for Interpretation of Untargeted LC-HRMS Data.

ACS measurement science au·2026

Same journal

Fully 3D-Printed Sampling-to-Detection Electrochemical Platform for Point-of-Care Measurement of Salivary Uric Acid.

ACS measurement science au·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 12, 2026

Synthesis, Assembly, and Characterization of Monolayer Protected Gold Nanoparticle Films for Protein Monolayer Electrochemistry

Synthesis, Assembly, and Characterization of Monolayer Protected Gold Nanoparticle Films for Protein Monolayer Electrochemistry

Published on: October 4, 2011

Reproducibly Modified Elastin-like Polymer Gold Electrode Surfaces.

Stanley Feeney¹, Marissa Morales¹, Galen Arnold²

¹Department of Chemical Engineering and Bioengineering, College of Engineering and Physical Sciences, University of New Hampshire, 33 Academic Way, Durham, New Hampshire 03824, United States.

ACS Measurement Science Au

|August 27, 2025

Summary

This summary is machine-generated.

Researchers optimized surface modification with elastin-like polymers (ELPs) for reproducible results. They identified nonspecific polymer interactions as the main cause of poor reproducibility in ELP surface modifications.

Keywords:

elastin-like polymers electrochemical impedance spectroscopy electrochemistry surface optimization surface reproducibility thiol modifications

More Related Videos

Regeneration of Arrayed Gold Microelectrodes Equipped for a Real-Time Cell Analyzer

Regeneration of Arrayed Gold Microelectrodes Equipped for a Real-Time Cell Analyzer

Published on: March 12, 2018

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen

Published on: June 3, 2018

Related Experiment Videos

Last Updated: May 12, 2026

Synthesis, Assembly, and Characterization of Monolayer Protected Gold Nanoparticle Films for Protein Monolayer Electrochemistry

Synthesis, Assembly, and Characterization of Monolayer Protected Gold Nanoparticle Films for Protein Monolayer Electrochemistry

Published on: October 4, 2011

Regeneration of Arrayed Gold Microelectrodes Equipped for a Real-Time Cell Analyzer

Regeneration of Arrayed Gold Microelectrodes Equipped for a Real-Time Cell Analyzer

Published on: March 12, 2018

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen

Published on: June 3, 2018

Area of Science:

Biomaterials Science
Polymer Chemistry
Surface Science

Background:

Elastin-like polymers (ELPs) are versatile for biomedical uses like drug delivery and tissue scaffolding.
ELPs offer tunable properties, including adjustable lower critical solution temperature and structure.
Characterization of ELPs in aqueous solutions is extensive, but surface characterization remains less explored.

Purpose of the Study:

To develop and optimize a reproducible method for modifying gold electrode surfaces with ELPs.
To investigate and identify the sources of inconsistency in ELP surface modifications.
To improve the reliability of surface-bound ELP characterization for biomedical applications.

Main Methods:

Developed a thiol-gold interaction method utilizing a single N-terminal cysteine residue for ELP surface modification.
Employed electrochemical impedance spectroscopy to tune modification parameters for reproducible charge-transfer resistance.
Quantified cysteine modification relative to ELP concentration using thiol reduction assays.

Main Results:

Optimized ELP surface modification parameters: 0.0125 mg/mL ELP for 30 min at 4 °C in 3.5 mM TCEP (pH 7.4).
Achieved reproducible charge-transfer resistance on the gold electrode surface.
Identified nonspecific polymer interactions as the primary source of poor reproducibility in ELP surface modification.

Conclusions:

Established an optimized, reproducible method for ELP surface modification on gold electrodes without cosurfactants.
Highlighted the critical role of controlling nonspecific polymer interactions for consistent surface functionalization.
Provided a foundation for more reliable characterization and application of ELP-modified surfaces in biomedical fields.