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The Association of ITGBL1 and LPPR4/PRG1 Expression Profile in Patients with Prostate Cancer History
Asmaalsadat Nikkhouy-Tanha1, Nazanin Nazari2, Maryam Moradi3
1Department of Plant Protection, College of Agricultural Biotechnology Sciences, Shahed University, Tehran, Iran.
Advanced Biomedical Research
|August 27, 2025
Summary
Elevated ITGBL1 gene expression is linked to prostate cancer. LPPR4/PRG1 gene expression showed no significant association with prostate cancer incidence in this study.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Prostate cancer is a leading cause of cancer mortality in men globally.
- While less common in Iran, it remains a significant cancer burden.
- Emerging research suggests genetic factors may influence prostate cancer risk.
Purpose of the Study:
- To investigate the association between ITGBL1 and LPPR4/PRG1 gene expression and prostate cancer.
- To evaluate potential genetic biomarkers for prostate cancer in the Iranian population.
Main Methods:
- Analysis of 40 prostate cancer tissues and 41 normal tissues.
- Gene expression profiling using TaqMan Real-time PCR.
- Statistical analysis of gene expression data.
Main Results:
- Significantly higher ITGBL1 gene expression was observed in prostate cancer tissues.
- No significant correlation was found between LPPR4/PRG1 expression and prostate cancer incidence.
- LPPR4/PRG1 expression showed no association in patients with a history of prostate cancer.
Conclusions:
- ITGBL1 may play a critical role in prostate cancer development and progression.
- Further research is needed to validate these findings in larger Iranian cohorts.
- ITGBL1 warrants further investigation as a potential biomarker for prostate cancer.
