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Updated: Sep 10, 2025
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Published on: May 10, 2021
Evaluation of a Novel Prognostic System for Surgically Resected Oral Cavity Carcinoma
Alisa Rybkin1, Victor Lee1, Melissa R Young1
1Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, USA.
Background:
The Oral Cavity Predictive Score (OCCPS) is a point-based system including T/N stage, LVSI, and grade that has been validated for predicting distant metastasis. We tested its ability to predict overall survival (OS) in surgically managed oral cavity carcinoma (OCC).
Methods:
Patients diagnosed 2010-2020 and treated with surgery were selected from the National Cancer Data Base (NCDB) and stratified into standard, intermediate, and high-risk categories using OCCPS. The Kaplan-Meier method compared OS in the whole cohort and select subgroups.
Results:
Of 32 317 patients (median follow-up 38.4 months), 51.7%, 22.5%, and 25.8% were classified into standard, intermediate, and high-risk groups, respectively. Five-year OS was 73.4%, 58.6%, and 39.3% (log rank p < 0.001). The OCCPS stratified patients with negative margins and absent ENE, and stage IVA-B disease (log rank p < 0.001).
Conclusion:
In patients with OCC managed with at least definitive surgery, the OCCPS successfully stratifies patients into standard, intermediate, and high-risk groups for prediction of OS.
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