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Lactoferrin in the Eternal City.

Piera Valenti1,2, Antimo Cutone3, Luigi Rosa1

  • 1Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.

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|August 27, 2025
PubMed
Summary
This summary is machine-generated.

Lactoferrin (Lf) research reveals its diverse roles beyond traditional functions, showing promise in treating infections, inflammation, and cancer. Future studies will explore its therapeutic potential further.

Keywords:
anti-inflammatoryimmunomodulationlactoferrinmultifunctional glycoproteintherapeutic peptides

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Area of Science:

  • Biochemistry
  • Immunology
  • Biomedical Science

Background:

  • Lactoferrin (Lf) is a multifunctional glycoprotein with known antimicrobial, anti-inflammatory, and immunomodulatory properties.
  • The established 'one-protein-one-function' paradigm is being challenged by emerging research on Lf.
  • Lf's complex biological activities necessitate a deeper understanding of its mechanisms.

Purpose of the Study:

  • To present the latest research findings on lactoferrin (Lf) from the XVIth International Conference.
  • To explore the expanding therapeutic applications of Lf in various biomedical fields.
  • To highlight key factors influencing Lf efficacy, such as source, iron saturation, and formulation.

Main Methods:

  • The content is based on presentations and discussions from the XVIth International Conference on Lactoferrin.
  • Research encompassed a wide range of studies, including in vitro, in vivo, and clinical investigations.
  • Focus areas included Lf's effects on biofilms, immune responses, iron metabolism, gut health, and cancer.

Main Results:

  • Lf demonstrates significant potential in anti-biofilm strategies and modulating immune responses.
  • Studies confirmed Lf's role in maintaining iron homeostasis and promoting gut health.
  • Evidence suggests Lf possesses cancer-inhibitory properties, warranting further investigation.

Conclusions:

  • Lactoferrin (Lf) exhibits a broad spectrum of biological activities, extending beyond its classical functions.
  • Source, iron saturation, and formulation (including recombinant and peptide derivatives) are critical determinants of Lf's therapeutic efficacy.
  • The XVIth International Conference underscored Lf's growing biomedical relevance and paved the way for future research.