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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
A Biophysics of Epigenetic Rejuvenation
1Department of Biomedical Sciences, School of Medicine, Nazarbayev University, 5/1 Kerei, Zhanibek Khandar Street, Astana 010000, Kazakhstan.
Abstract:
We present a synthesis based on epigenetics, machine learning and polymer physics from which emerges new relationships between the thermodynamic Flory-Huggins parameter (χ), epigenetic age (eAge) and Shannon entropy. Using a framework for the estimation of χ in the nuclear environment we show that χ∝eAge-1 and χ∝Shannon Entropy-1. As cells age, epigenetic drift results in "smoothing out" of the epigenetic landscape reducing the magnitude of χ. Epigenetic rejuvenation reverses epigenetic drift and restores χ to levels found in young cells with concomitant reduction in both eAge and Shannon entropy.
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