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Nonsense-Mediated mRNA Decay: Mechanisms and Recent Implications in Cardiovascular Diseases

Fasilat Oluwakemi Hassan1,2, Md Monirul Hoque1,2, Abdul Majid1,2

  • 1Department of Physiology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Cells
|August 27, 2025
PubMed

Insights

Nonsense-mediated mRNA decay (NMD) regulates gene expression and prevents disease by degrading faulty mRNAs. Modulating NMD shows therapeutic potential for cardiovascular diseases and other genetic disorders.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Nonsense-mediated mRNA decay (NMD) is a conserved cellular surveillance pathway.
  • NMD degrades messenger RNAs (mRNAs) with premature termination codons (PTCs).
  • This process prevents the production of truncated and potentially harmful proteins.

Purpose of the Study:

  • To review the functional implications of NMD in human diseases.
  • To explore the therapeutic potential of NMD modulation, particularly for cardiovascular disease.
  • To examine NMD's role in genetic disorders and personalized medicine.

Main Methods:

  • Literature review of NMD pathways and their involvement in disease.
  • Analysis of NMD's regulatory mechanisms and impact on gene expression.
  • Exploration of therapeutic strategies targeting NMD components.

Main Results:

  • NMD dysregulation is linked to various diseases, including dilated cardiomyopathy, cancer, and neurodevelopmental disorders.
  • Modulating NMD may offer therapeutic benefits for genetically induced cardiovascular conditions.
  • NMD's role in gene regulation supports its application in personalized medicine.

Conclusions:

  • NMD is a critical pathway with significant implications for human health and disease.
  • Targeting NMD presents a promising therapeutic avenue for cardiovascular diseases and other genetic conditions.
  • Further research is essential to fully elucidate NMD's role in disease prevention and treatment.
Keywords:
cardiovascular diseases (CVDs)nonsense-mediated mRNA decay (NMD)premature termination codon (PTC)up-frameshift proteins (UPFs)

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